Publications

Selected work in neuroimaging, dementia, and medical AI.

현재까지 BREIN Lab에서 수행한 주요 연구 성과와 논문들을 소개합니다.

2025 Neuroimaging Biomarkers Journal

Occipital Enlarged Perivascular Spaces Associated with Cognitive Decline, Neurodegeneration and Tau Pathology in Aging and Alzheimer's Disease

YH Jung, W Kim, H Seo, SY Lee, H Lee, JK Seong, WJ Lee, and Y Noh

노화 및 알츠하이머병에서 후두엽 enlarged perivascular spaces와 인지저하, 신경퇴행, tau pathology의 관련성을 분석합니다.

Journal of Cerebral Blood Flow and Metabolism 45 (1), 423-423, 2025

Physical activity, Alzheimer plasma biomarkers, and cognition
2025 Dementia AI / 치매 AI Journal

Physical activity, Alzheimer plasma biomarkers, and cognition

SA Kim, D Shin, H Ham, Y Kim, Y Gu, HJ Kim, DL Na, H Zetterberg, and others

신체활동, 알츠하이머병 혈장 바이오마커, 인지기능 사이의 관련성을 분석합니다.

JAMA Network Open 8 (3), e250096, 2025

Real-world prediction of preclinical Alzheimer's disease with a deep generative model
2023 Dementia AI / 치매 AI Journal

Real-world prediction of preclinical Alzheimer's disease with a deep generative model

Uiwon Hwang, Sung-Woo Kim, Dahuin Jung, SeungWook Kim, Hyejoo Lee, Sang Won Seo, Joon-Kyung Seong, and Sungroh Yoon

실제 임상 데이터에서 딥 생성 모델을 활용해 전임상 알츠하이머병을 예측합니다.

Artificial Intelligence in Medicine, October 2023

Sex differences in the structural rich-club connectivity in patients with Alzheimer's disease
2023 Brain Network Journal

Sex differences in the structural rich-club connectivity in patients with Alzheimer's disease

Soo-Jong Kim, Youn Jung Bae, Yu Hyun Park, Hyemin Jang, Jun Pyo Kim, Sang Won Seo, Joon-Kyung Seong, and Geon Ha Kim

알츠하이머병 환자의 rich-club 구조 연결성에서 나타나는 성별 차이를 분석합니다.

Frontiers in Aging Neuroscience, September 2023

Differentiation between multiple sclerosis and neuromyelitis optica spectrum disorder using a deep learning model
2023 Medical AI Journal

Differentiation between multiple sclerosis and neuromyelitis optica spectrum disorder using a deep learning model

Jin Myoung Seok, Wanzee Cho, Yeon Hak Chung, Hyunjin Ju, Sung Tae Kim, Joon-Kyung Seong, and Ju-Hong Min

딥러닝 모델을 이용해 다발성 경화증과 시신경척수염 범주질환을 구분합니다.

Scientific Reports, July 2023

Effects of the APOE e4 Allele on the Relationship Between Tau and Amyloid-beta in Early- and Late-Onset Alzheimer's Disease
2023 Dementia AI / 치매 AI Journal

Effects of the APOE e4 Allele on the Relationship Between Tau and Amyloid-beta in Early- and Late-Onset Alzheimer's Disease

Jae Myeong Kang, Jeong-Hyeon Shin, Woo-Ram Kim, Seongho Seo, Haeun Seo, Sang-Yoon Lee, Kee Hyung Park, Duk L Na, Nobuyuki Okamura, Joon-Kyoung Seong, and Young Noh

알츠하이머병 발병 시기별 그룹에서 APOE e4가 tau와 amyloid-beta 관계에 미치는 영향을 연구합니다.

Journal of Alzheimer's Disease, June 2023

Local striatal volume and motor reserve in drug-naive Parkinson's disease
2022 Neuroimaging Biomarkers Journal

Local striatal volume and motor reserve in drug-naive Parkinson's disease

Seong Ho Jeong, Eun-Chong Lee, Seok Jong Chung, Hye Sun Lee, Jin Ho Jung, Young H. Sohn, Joon-Kyung Seong, and Phil Hyu Lee

약물 치료 전 파킨슨병에서 국소 선조체 부피 패턴과 운동 예비능의 관계를 분석합니다.

Nature npj Parkinson's Disease, September 2022

On the reliability of deep learning-based classification for Alzheimer's disease: Multi-cohorts, multi-vendors, multi-protocols, and head-to-head validation
2022 Dementia AI / 치매 AI Journal

On the reliability of deep learning-based classification for Alzheimer's disease: Multi-cohorts, multi-vendors, multi-protocols, and head-to-head validation

Yeong-Hun Song, Jun-Young Yi, Young Noh, Hyemin Jang, Sang Won Seo, Duk L. Na, and Joon-Kyung Seong

코호트, 장비 제조사, MRI 프로토콜이 다른 환경에서 딥러닝 기반 알츠하이머병 분류의 신뢰성을 검증합니다.

Frontiers in Neuroscience, September 2022

Harmonization of Multicenter Cortical Thickness Data by Linear Mixed Effect Model
2022 Neuroimaging Biomarkers Journal

Harmonization of Multicenter Cortical Thickness Data by Linear Mixed Effect Model

SeungWook Kim, Sung-Woo Kim, Young Noh, Phil Hyu Lee, Duk L. Na, Sang Won Seo, and Joon-Kyung Seong

다기관 피질 두께 데이터의 site effect를 줄이기 위한 조화화 방법을 제시합니다.

Frontiers in Aging Neuroscience, June 2022

Regional Abeta-tau interactions promote onset and acceleration of Alzheimer's disease tau spreading
2022 Brain Network Journal

Regional Abeta-tau interactions promote onset and acceleration of Alzheimer's disease tau spreading

Wha Jin Lee, Jesse A. Brown, Hye Ryun Kim, Renaud La Joie, Hanna Cho, Chul Hyoung Lyoo, Gil D. Rabinovici, Joon-Kyung Seong, and William W. Seeley

지역별 amyloid-beta와 tau 상호작용이 알츠하이머병 tau 전파에 어떻게 기여하는지 보여줍니다.

Neuron, June 2022

Association of subcortical structural shapes with fatigue in neuromyelitis optica spectrum disorder
2022 Neuroimaging Biomarkers Journal

Association of subcortical structural shapes with fatigue in neuromyelitis optica spectrum disorder

Jin Myoung Seok, Wanzee Cho, Doo-Hwan Son, Jong Hwa Shin, Eun Bin Cho, Sung Tae Kim, Byoung Joon Kim, Joon-Kyung Seong, and Ju-Hong Min

시신경척수염 범주질환에서 피질하 구조의 형태 변화와 피로 증상의 관계를 분석합니다.

Scientific Reports, January 2022

Distinctive mediating effects of subcortical structure changes on the relationships between amyloid or vascular changes and cognitive decline
2021 Dementia AI / 치매 AI Journal

Distinctive mediating effects of subcortical structure changes on the relationships between amyloid or vascular changes and cognitive decline

Na-Yeon Jung, Jeong-Hyeon Shin, Hee Jin Kim, Hyemin Jang, Seunghwan Moon, Seung Joo Kim, Yeshin Kim, Soo Hyun Cho, Ko Woon Kim, Junpyo Kim, Young Hee Jung, Sung Tae Kim, Eun-Joo Kim, Duk L Na, Jacob W Vogel, Sangjin Lee, Joon-Kyung Seong, and Sang Won Seo

피질하 구조 변화가 amyloid, 혈관 변화, 인지 저하 사이의 관계를 어떻게 매개하는지 분석합니다.

Frontiers in Neurology, December 2021

Effect of education on functional network edge efficiency in Alzheimer's disease
2021 Brain Network Journal

Effect of education on functional network edge efficiency in Alzheimer's disease

Yeshin Kim, Sung-Woo Kim, Sang Won Seo, Hyemin Jang, Ko Woon Kim, Soo Hyun Cho, Si Eun Kim, Seung Joo Kim, Jin San Lee, Sung Tae Kim, Duk L. Na, Joon-Kyung Seong, and Hee Jin Kim

알츠하이머병에서 기능적 네트워크 edge efficiency를 통해 교육과 관련된 인지 예비능을 연구합니다.

Scientific Reports, August 2021

Harmonisation of PET imaging features with different amyloid ligands using machine learning-based classifier
2021 Medical AI Journal

Harmonisation of PET imaging features with different amyloid ligands using machine learning-based classifier

Sung Hoon Kang, Jeonghun Kim, Jun Pyo Kim, Soo Hyun Cho, Yeong Sim Choe, Hyemin Jang, Hee Jin Kim, Seong-Beom Koh, Duk L. Na, Joon-Kyung Seong, and Sang Won Seo

서로 다른 amyloid ligand에서 얻은 PET 영상 특징을 머신러닝으로 조화화합니다.

European Journal of Nuclear Medicine and Molecular Imaging, July 2021